Isotretinoin can change lives: it clears severe, scarring acne when other treatments fail. But it’s powerful, so you need to know what to expect and how to stay safe. This page gives clear, practical info you can use before and during treatment.
Isotretinoin is an oral vitamin A derivative that shrinks oil glands, lowers oil production, and reduces pore-clogging and inflammation. Doctors usually reserve it for cystic or widespread acne that hasn’t improved with antibiotics or topical meds. Most courses run 4–6 months; a full course often results in long-term improvement for many people.
Expect a slow start. Some people see a temporary flare in the first weeks before skin clears. Dose is tailored to body weight and acne severity. Your prescriber will explain the target cumulative dose and follow-up plan.
Common effects are dry skin, chapped lips, nosebleeds, dry eyes, and increased sensitivity to the sun. Less common but important issues: raised liver enzymes and high triglycerides. Blood tests are done before starting and periodically during treatment to check liver function and lipids.
Isotretinoin causes severe birth defects. If you can get pregnant, you must follow strict pregnancy-prevention rules: reliable contraception, regular pregnancy tests, and clear counseling from your prescriber. Do not become pregnant during treatment or for at least one month after stopping.
Mental health changes have been reported by some patients. If you notice new or worsening mood symptoms, suicidal thoughts, or sudden behavioral changes, contact your healthcare provider right away.
Avoid vitamin A supplements and prescription retinoids while on treatment to prevent overdose. Skip waxing and aggressive skin procedures during and for several months after therapy — your skin heals differently and can scar more easily.
Practical skin-care tips: use a gentle, fragrance‑free cleanser, heavy moisturizer, and SPF 30+ daily. Lip balm is a must. If contact lenses feel uncomfortable, switch to glasses until eyes feel normal. Don’t donate blood while on isotretinoin and for one month after stopping.
Follow-up matters. Keep scheduled lab checks and appointments, and tell your provider about any new symptoms. If you have a history of liver disease, high triglycerides, or mood disorders, discuss risks clearly before starting.
Want credible next steps? Talk to a dermatologist, ask about expected timelines and monitoring, and get written instructions about contraception and lab testing. If you need more articles or patient-friendly resources, search Farmapram for related guides and reviews to help you make informed choices.
