Want an antidepressant that often avoids the sexual side effects common with SSRIs? Wellbutrin SR is a common choice for depression and for helping people quit smoking. It works a bit differently than many antidepressants and can boost energy and motivation for some people.
The usual start is 150 mg once daily for three days, then 150 mg twice daily. Doses are generally spaced by at least 8 hours and should not be taken late in the day to prevent insomnia. The typical maximum for SR is 400 mg per day, but higher doses raise the risk of seizures. If your prescriber switches you to an extended‑release (XL) form, that is usually once daily instead of twice.
Take the tablet whole—don’t crush or chew sustained‑release tablets. You can take it with or without food. If you miss a dose, skip it if it’s close to your next scheduled dose; don’t double up.
Some people notice more energy or better focus within 1–2 weeks, but mood improvements often take 4–6 weeks. Keep taking it even if you don't feel better right away. If you feel worse, have new thoughts of harming yourself, or notice sudden mood swings, contact your clinician immediately.
Wellbutrin SR is also prescribed for smoking cessation (sold as Zyban in that use). When used for quitting, your prescriber will give a schedule that often starts before your quit date so the medicine is active when you stop smoking.
Compared with many SSRIs, bupropion usually causes less sexual dysfunction and may lead to modest weight loss for some people. It can increase focus and energy, but it can also cause jitteriness or trouble sleeping for others.
Important safety tips: Do not use Wellbutrin if you have a seizure disorder, a history of bulimia or anorexia, or if you are withdrawing from heavy alcohol use—these raise seizure risk. Avoid combining it with MAO inhibitors; wait at least 14 days after stopping an MAOI before starting bupropion. Tell your doctor about other meds you take—some drugs and supplements can raise seizure risk or change blood levels.
Blood pressure can rise on bupropion, so get it checked if you have hypertension. Also mention pregnancy or breastfeeding to your prescriber—decisions about treatment should be individualized.
If side effects are annoying—like dry mouth, headache, nausea, or sleep trouble—talk to your prescriber about dose timing, switching forms (SR vs XL), or alternative medicines. Never stop suddenly without a plan; your doctor will guide a safe change or taper.
Questions you can ask your clinician: Is this dose right for me? How long before I expect improvement? Can this help me quit smoking? What should make me call you right away? Those simple questions help you get the most from treatment.
